{"id":1021,"date":"2022-09-08T18:19:06","date_gmt":"2022-09-08T18:19:06","guid":{"rendered":"https:\/\/nootopia.com\/blog\/?p=1021"},"modified":"2022-10-01T15:53:48","modified_gmt":"2022-10-01T15:53:48","slug":"lions-mane-benefits","status":"publish","type":"post","link":"https:\/\/nootopia.com\/blog\/lions-mane-benefits\/","title":{"rendered":"Lion&#8217;s Mane Benefits"},"content":{"rendered":"\n<p>Lion\u2019s mane, or <em>Hericium erinaceus<\/em>, is an edible mushroom which is a part of traditional Asian medicine. It\u2019s the most popular mushroom for its nootropics and neurogenesis benefits. In this article, we will cover everything you need to know about lion\u2019s mane, from benefits to side effects.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What is Lion&#8217;s Mane mushroom?\u00a0<\/h2>\n\n\n\n<p>Lion\u2019s mane (Yamabushitake<em> <\/em>or hou tou gu) is an important medicinal and culinary mushroom in oriental cultures. This mushroom grows mostly on dead or old trees in <strong>Asia<\/strong> and across <strong>North America<\/strong>. Since it is white in color and has dangling spines like a beard, it is relatively easy to recognize it on the hardwood trees.&nbsp;<\/p>\n\n\n\n<p>Historically, Lion\u2019s mane has been an important remedy in Chinese and Japanese <strong>traditional medicines<\/strong>. This mushroom is nutritive to lungs, spleen, liver, kidneys, and the heart. Asian cultures also believe that it enhances digestion, helps with ulcers and gastritis, as well as general weakness and insomnia.<span class=\"custom-citation\" data-id=\"ref-1\"><\/span>&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/14-1-1024x682.png\" alt=\"lion's mane mushroom \" class=\"wp-image-1040\" srcset=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/14-1-1024x682.png 1024w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/14-1-300x200.png 300w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/14-1-768x511.png 768w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/14-1-1536x1023.png 1536w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/14-1.png 1622w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What are Lion\u2019s mane\u2019s active substances?<\/h2>\n\n\n\n<p>Many <strong>polysaccharides<\/strong> in the cell walls and fruiting bodies of lion\u2019s mane have medicinal benefits. For example, heteroxyloglucans, galacto-xyloglucans, xylans, and glucoxylans inhibit cell growth and cause apoptosis (cell suicide) in abnormal cells. Other polysaccharides <strong>reduce oxidative stress<\/strong> and protect cells from premature apoptosis.&nbsp;<\/p>\n\n\n\n<p><strong>Terpenoids<\/strong> are smaller hydrocarbons with lower molecular weights. There are two classes of terpenoids unique to lion\u2019s mane, hericenones and erinacines. These two easily cross the blood-brain barrier to support and protect neurons.<span class=\"custom-citation\" data-id=\"ref-1\"><\/span> Additionally, they induce nerve growth factor synthesis.<span class=\"custom-citation\" data-id=\"ref-2\"><\/span><\/p>\n\n\n\n<p>Other chemicals in lion\u2019s mane, corallocin A, hericerin, isohericenol, and N-de-phenylethyl isohericerin increase brain-derived neurotrophic factor in rodent neurons in test tube studies.<span class=\"custom-citation\" data-id=\"ref-3\"><\/span><\/p>\n\n\n\n<p>All <em>Hericium erinaceus <\/em>extracts can inhibit the growth of some bacteria, such as <em>Staphylococcus aureus<\/em> (MRSA) and <em>Salmonella<\/em> in test tube studies.<span class=\"custom-citation\" data-id=\"ref-4\"><\/span><span class=\"custom-citation\" data-id=\"ref-5\"><\/span><\/p>\n\n\n\n<p>Generally, lion\u2019s mane is a great source of nutrients necessary for proper brain functioning, but also for other vital organs and functions.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Brain, mental health, and cognitive benefits of Lion\u2019s Mane<\/h2>\n\n\n\n<p>Brain, mental health, and cognitive benefits of lion\u2019s mane include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Boost mood<\/li><li>Improves focus<\/li><li>Helps with learning<\/li><li>Support a calm and flow state<\/li><li>Improves brain cell regeneration<\/li><li>Helps with memory<\/li><\/ul>\n\n\n\n<p>The following is how lion\u2019s mane deliver these brain benefits.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Counteracts age-related cognitive impairment<\/h3>\n\n\n\n<p>Age-related cognitive impairment can arise due to<span class=\"custom-citation\" data-id=\"ref-6\"><\/span>:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased in inflammation<\/li><li>Reduced neurogenesis<\/li><li>Reduced ability to refold proteins correctly<\/li><li>Increased oxidative stress<\/li><li>Mitochondria dysfunction<\/li><li>Nutrient deficiencies from reduced appetite and poorer digestion<\/li><\/ul>\n\n\n\n<p>Lion\u2019s mane may mitigate many of these age-related physical and mental decline.&nbsp;<\/p>\n\n\n\n<p>A study included 30 Japanese women and men, aged 50 to 80, with mild cognitive impairment. There were 2 groups &#8211; one that received four tablets containing 96% of lion\u2019s mane dry powder, 3 times a day for 16 weeks; and the other group received a placebo. Both groups then underwent cognitive tests, which measured verbal, drawing, visuospatial, and construction abilities.<\/p>\n\n\n\n<p>The lion\u2019s mane group were on a significantly higher level on the cognitive function scale than the control group. Furthermore, the scores increased the longer the subjects consumed lion\u2019s mane. However, cognitive scores dropped significantly 4 weeks after the intake of <em>Hericium erinaceus <\/em>stopped.<span class=\"custom-citation\" data-id=\"ref-7\"><\/span> Nevertheless, these results show that lion\u2019s mane can help <strong>mild cognitive impairment<\/strong>.&nbsp;<\/p>\n\n\n\n<p>In one study, mice received lion\u2019s mane extract over the course of 30 days. Lion\u2019s mane reduced the formation of plaques and enhanced the formation of new neurons and the connections between them.<span class=\"custom-citation\" data-id=\"ref-8\"><\/span><\/p>\n\n\n\n<p>A rat study researched the role of polysaccharides found within lion\u2019s mane, and their possible neuroprotective effects. Rats received 250\u03bcg\/ml of lion\u2019s mane polysaccharides, which induced higher cell viability, prevented cell shrinkage, and degradation.<span class=\"custom-citation\" data-id=\"ref-9\"><\/span><\/p>\n\n\n\n<p>Additionally, a mice study investigated the role of lion\u2019s mane in learning and memory deficits. Mice received 10\u03bcg of <strong>amyloid \u03b2<\/strong>, which induces cognitive impairment, and ate a diet based on lion\u2019s mane for 23 days. The results demonstrated that lion\u2019s mane prevented spatial short-term and visual recognition <strong>memory deficits<\/strong> caused by amyloid \u03b2. These findings support the idea that lion\u2019s mane reduces cognition-related issues associated with amyloid \u03b2.<span class=\"custom-citation\" data-id=\"ref-10\"><\/span> However, we still need a human trial to confirm this benefit of lion\u2019s mane.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"685\" src=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/24-1-1024x685.png\" alt=\"open hand with a brain drawing \" class=\"wp-image-1041\" srcset=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/24-1-1024x685.png 1024w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/24-1-300x201.png 300w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/24-1-768x514.png 768w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/24-1-1536x1028.png 1536w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/24-1.png 1614w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Improves acetylcholine<\/h3>\n\n\n\n<p><a href=\"https:\/\/nootopia.com\/blog\/what-is-acetylcholine-and-what-are-its-important-roles\/\" target=\"_blank\" rel=\"noreferrer noopener\">Acetylcholine<\/a> is one of your most important neurotransmitters for cognitive functions, memory, and brain health.<\/p>\n\n\n\n<p>Furthermore, lion\u2019s mane enhances acetylcholine concentrations in blood and hypothalamus in mice. The mushroom polysaccharides work by increasing enzymes that produce acetylcholine. This mechanism is different from many other cholinergic nootropics which work by inhibiting the enzyme that breaks down acetylcholine. Therefore, lion\u2019s mane combined with other cholinergics may have additive effects on brain acetylcholine levels.<\/p>\n\n\n\n<p>Also, by enhancing nerve growth factor, lion\u2019s mane preserves and stimulates the growth of the basal forebrain\u2019s cholinergic neurons.<span class=\"custom-citation\" data-id=\"ref-11\"><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Protects and supports the growth of hippocampal neurons<\/h3>\n\n\n\n<p>The hippocampus is your brain\u2019s memory center. It tends to shrink in adults with mood issues. Animal studies suggest that lion\u2019s mane may help with mood by enhancing neurogenesis in the hippocampus.<\/p>\n\n\n\n<p>A study involving male mice focused on the effect of lion\u2019s mane on mood. One group received a lion&#8217;s mane dosage, 20 or 60mg\/kg body weight, once a day for four weeks, while the other group received saline of the same amount and duration. They found that a lion&#8217;s mane enhanced the formation of new neurons and synapses within the hippocampus. Behavioral tests also showed that the lion\u2019s mane group moved and explored more, and had better mood and motivation amidst stress.<span class=\"custom-citation\" data-id=\"ref-12\"><\/span>&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Supports healthy neurotransmitter and inflammation balance<\/h3>\n\n\n\n<p>Day to day stress can throw off neurotransmitters and increase inflammation in the brain. These can reduce cognitive function, energy levels, motivation, focus, and mood.<\/p>\n\n\n\n<p>In mice, ethanolic extract of lion\u2019s mane high in erinacine A seems to support mood and cognitive functions through neurotransmitter and inflammation balance.<\/p>\n\n\n\n<p>Mice received 100, 200, or 400 mg\/kg body weight of the extract once a day for 4 weeks. Two weeks into the study, they received restraint stress for 2 weeks. The control group was not exposed to these protocols, nor lion\u2019s mane.&nbsp;<\/p>\n\n\n\n<p>Stressed mice typically move less in water and when held from the tail, while exploring more in elevated plus maze tests. Along with these behaviors, their dopamine, serotonin, and norepinephrine levels drop as their inflammatory cytokines like tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) increase.&nbsp;<\/p>\n\n\n\n<p>Animals that received the mushroom had <strong>increased levels of dopamine, serotonin, and norepinephrine<\/strong>, as well as decreased TNF-alpha and IL-6. They also had increased brain-derived neurotrophic factor levels. These results were especially significant in groups that received 200 and 400 mg\/kg body weight.<span class=\"custom-citation\" data-id=\"ref-13\"><\/span>&nbsp;<\/p>\n\n\n\n<p>These results suggest that lion\u2019s mane may support mood by promoting neurotransmitter and inflammation balance.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Stimulates neurotrophins&nbsp;&nbsp;<\/h3>\n\n\n\n<p>Neurotrophins are proteins that support the survival, growth, and function of neurons. There are many of these, but two of the most important ones are <a href=\"https:\/\/nootopia.com\/blog\/role-of-bdnf\/\" target=\"_blank\" rel=\"noreferrer noopener\">brain-derived neurotrophic factor (BDNF)<\/a> and nerve growth factor (NGF). BDNF is important for learning, memory, mood, and <a href=\"https:\/\/bioptimizers.com\/blog\/how-to-maximize-your-sleep-quality\/\" target=\"_blank\" rel=\"noreferrer noopener\">deep sleep<\/a>. NGF supports sympathetic, sensory, and cholinergic neurons in the forebrain.&nbsp;<\/p>\n\n\n\n<p>Cell-based studies show that lion\u2019s mane constituents increase NGF and BDNF production.<span class=\"custom-citation\" data-id=\"ref-2\"><\/span><span class=\"custom-citation\" data-id=\"ref-3\"><\/span>&nbsp;<\/p>\n\n\n\n<p>In a placebo-controlled study involving 30 menopausal women, lion\u2019s mane effectively boosted mood, reduced irritability, sleep, and wellbeing. The authors speculated that the lion\u2019s mane helped by boosting nerve growth factor.<span class=\"custom-citation\" data-id=\"ref-14\"><\/span><\/p>\n\n\n\n<p>In a study in overweight\/obese patients, 77 volunteers received lion\u2019s mane. The lion\u2019s mane extract didn\u2019t significantly boost their blood BDNF, but it did boost their precursor to BDNF levels in the blood. The subjects also had improved mood, calmness, and sleep.<span class=\"custom-citation\" data-id=\"ref-15\"><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Support neuronal repair and regeneration<\/h3>\n\n\n\n<p>Day-to-day stress and elements can create minor damages to the nervous system. Lion\u2019s mane supports the repair of neurons and other cells in the nervous system.&nbsp;<\/p>\n\n\n\n<p>Having in mind the detrimental effects of nervous system injuries, neural re-connections are of huge importance. A study using dissociated chick embryo cells from the brain and spinal cord investigated the importance of lion\u2019s mane for neurite outgrowth. 50\u00b5g\/ml lion\u2019s mane extract caused increased neurite outgrowth in the brain (by 20.47%) and in the special cord (by 22.47%).<span class=\"custom-citation\" data-id=\"ref-16\"><\/span><\/p>\n\n\n\n<p>Another in vitro study aimed to investigate how lion\u2019s mane affects myelination, the process which makes insulating myelin sheaths to surround the axon. The lion\u2019s mane extract promoted faster myelination, which started earlier than in the control cells.<span class=\"custom-citation\" data-id=\"ref-17\"><\/span>&nbsp;<\/p>\n\n\n\n<p>A rat study focused on lion\u2019s mane polysaccharides. Rat cells received doses of either lion\u2019s mane extract, or nerve growth factor and brain-derived nerve factor. The results showed enhanced growth of adrenal nerve cells and neurite outgrowth, which was even higher than by nerve growth factor or brain-derived nerve factor.<span class=\"custom-citation\" data-id=\"ref-18\"><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Improves sleep&nbsp;<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"684\" src=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/33-1-1-1024x684.png\" alt=\"man sleeping in bed\" class=\"wp-image-1042\" srcset=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/33-1-1-1024x684.png 1024w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/33-1-1-300x200.png 300w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/33-1-1-768x513.png 768w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/33-1-1-1536x1027.png 1536w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/33-1-1.png 1616w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Lion\u2019s mane can uniquely help with sleep. It\u2019s not a sedative but it improves sleep quality through supporting brain balance.<\/p>\n\n\n\n<p>A study involved 77 overweight individuals who experienced mood or sleep problems. Participants received oral lion\u2019s mane supplement for 8 weeks, which resulted in a <strong>reduction of mood and sleep issues<\/strong>. They also had increased pro-BDNF levels.<\/p>\n\n\n\n<p>One study included 8 female students who took 6 lion\u2019s mane tablets a day, over a 4 week period. Based on a self-administered survey, lion\u2019s mane supplementation <strong>improved their sleep quality<\/strong> and the general feeling of wellbeing.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other health benefits of lion\u2019s mane<\/h2>\n\n\n\n<p>Animal and cell-based studies have demonstrated many benefits of lion\u2019s mane, although clinical evidence is still missing for a lot of them. Please note that we include this information for educational purposes only. We\u2019re not suggesting that lion\u2019s mane can treat any conditions. It\u2019s not approved to treat or diagnose any conditions. Please see your doctor for appropriate diagnosis and treatment.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Inhibits bacterial growth<\/h3>\n\n\n\n<p><em>Hericium erinaceus<\/em> is also an effective agent against bacteria. It works against gram-positive and gram-negative bacteria.<span class=\"custom-citation\" data-id=\"ref-4\"><\/span><\/p>\n\n\n\n<p>It successfully kills <em>Helicobacter pylori <\/em>and<em> Staphylococcus aureus <\/em><span class=\"custom-citation\" data-id=\"ref-19\"><\/span> Thus, the lion&#8217;s mane is a great antibacterial agent.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Nourishes and protects the digestive tract<\/h3>\n\n\n\n<p>Lion\u2019s mane protects and strengthens your digestive tract. First off, lion\u2019s mane nourishes and protects your spleen and liver.<span class=\"custom-citation\" data-id=\"ref-1\"><\/span><\/p>\n\n\n\n<p>Furthermore, lion\u2019s mane strengthens the stomach barrier protection against acid.<span class=\"custom-citation\" data-id=\"ref-20\"><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Promotes heart health<\/h3>\n\n\n\n<p>Lion\u2019s mane can also be beneficial for your heart and cardiovascular system.&nbsp;<\/p>\n\n\n\n<p>Lion\u2019s mane can thin the blood. Hericenone B, found in lion\u2019s mane ethanol extract, inhibits collagen-induced platelet aggregation. However, it did not inhibit any other platelet aggregation pathway, like thrombin. Extensive research on rabbit and human platelets supports this.<span class=\"custom-citation\" data-id=\"ref-21\"><\/span><\/p>\n\n\n\n<p>Oxidized low-density lipoprotein (LDL cholesterol) is very bad for cardiovascular health because it\u2019s more likely to harden the arteries. A study showed that a hexane extract of lion\u2019s mane <strong>inhibits the oxidation of LDL cholesterol<\/strong>.<span class=\"custom-citation\" data-id=\"ref-21\"><\/span> This is one of the ways that lion\u2019s mane can help your cardiovascular health.&nbsp;<\/p>\n\n\n\n<p>A high-fat diet is a risk factor for the development of many cardiovascular diseases in mice, which is equivalent to a human junk food diet. A mice study aimed to investigate the role of lion\u2019s mane in fat metabolism. Mice ate a high-fat diet for 28 days. One group received a daily dose of lion\u2019s mane, while the control group received the high-fat diet only. The group that had lion\u2019s mane incorporated into their diet had 27% lower triglyceride levels and 42% less weight gain than the control group. Thus, lion\u2019s mane <strong>promotes fat metabolism and healthy blood lipids,<\/strong> and somewhat protects your cardiovascular system from poor diet.<span class=\"custom-citation\" data-id=\"ref-22\"><\/span><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/42-1-1024x576.png\" alt=\"human heart diagram\" class=\"wp-image-1043\" srcset=\"https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/42-1-1024x576.png 1024w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/42-1-300x169.png 300w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/42-1-768x432.png 768w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/42-1-1536x864.png 1536w, https:\/\/nootopia.com\/blog\/wp-content\/uploads\/2022\/09\/42-1.png 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Improves cellular antioxidant defense<\/h3>\n\n\n\n<p>Oxidative stress is essential in many situations, but too much of it can be bad. For example, it can cause fatigue, interfere with cognitive function, and contribute to many diseases.<\/p>\n\n\n\n<p>Lion\u2019s mane activates cellular pathways that counteract oxidative stress. In a mice study, lion\u2019s mane extract adjusted the synthesis and processing of nitric oxide, superoxide dismutase, and malondialdehyde within serum.<span class=\"custom-citation\" data-id=\"ref-23\"><\/span><\/p>\n\n\n\n<p>In another study, scientists investigated the antioxidant properties of multiple mushroom species, including lion\u2019s mane. The antioxidant index described antioxidant potentials. Lion\u2019s mane is among the top three species with strongest antioxidant capabilities, having an antioxidant index of 17.7%.<span class=\"custom-citation\" data-id=\"ref-24\"><\/span>&nbsp;<\/p>\n\n\n\n<p>One more mice study dealt with lion\u2019s mane effect on hippocampal neurons treated with hydrogen peroxide. The hot water extract of <em>Hericium erinaceus<\/em> significantly increased the activity of antioxidant enzymes and viability of neurons treated with hydrogen peroxide, as well as decreased the amount of reactive oxygen species.<span class=\"custom-citation\" data-id=\"ref-25\"><\/span>&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Boosts your immunity<\/h3>\n\n\n\n<p>Our immunity is the primary shield against different bacteria and viruses. Lion\u2019s mane might have a beneficial effect even on your immune system.<\/p>\n\n\n\n<p>One mice study researched the immunomodulatory effects of lion\u2019s mane. This mushroom improved both cell-mediated and humoral immunity, meaning killer cells and antibody efficacy. These properties are likely related to the lion\u2019s mane ability to regulate gut mucosal immune barrier.<span class=\"custom-citation\" data-id=\"ref-26\"><\/span><\/p>\n\n\n\n<p>Apart from the adaptive immunity covered by the previous study, lion\u2019s mane also enhances innate immunity. Mice injected with<em> Salmonella<\/em> species had 4 times longer lifespan if they also received lion\u2019s mane extracts. This increased resistance to bacterial infections comes from stronger immune activation.<span class=\"custom-citation\" data-id=\"ref-27\"><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Promotes a balanced inflammatory response<\/h3>\n\n\n\n<p>Lion\u2019s mane, like many other medicinal mushrooms, support both immune system readiness and balance. It often helps balance excess inflammation from the modern diet and lifestyle and aging.&nbsp;<\/p>\n\n\n\n<p>Obesity and unhealthy metabolism can contribute to chronic inflammation. Lion\u2019s mane counteracts excess inflammation from macrophages in fat tissues.<span class=\"custom-citation\" data-id=\"ref-28\"><\/span><\/p>\n\n\n\n<p>In a mouse model of gut inflammation, 200 and 500 mg of lion\u2019s mane extract mitigates the inflammation and protects the gut barrier. As a result, the animals had less digestive symptoms.<span class=\"custom-citation\" data-id=\"ref-23\"><\/span><\/p>\n\n\n\n<p>Similar results are visible within microglia, where lion\u2019s mane extracts have anti-inflammatory activity and reduce neurotoxicity in the brain.<span class=\"custom-citation\" data-id=\"ref-25\"><\/span><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Support healthy blood sugar control<\/h3>\n\n\n\n<p>Several animal studies show that lion\u2019s mane can improve blood sugar control. It inhibits \u03b1-glucosidase, an enzyme that breaks carbohydrates down, slowing down carbohydrate absorption.<span class=\"custom-citation\" data-id=\"ref-29\"><\/span> Also, lion\u2019s mane may also help with blood sugar by balancing inflammation, counteracting oxidative stress, and supporting other aspects of heart health.<\/p>\n\n\n\n<p>A study included rats with diabetes, who received 100 or 200mg\/kg body weight of <em>H. erinaceus<\/em> extract for 28 days. The results showed that lion\u2019s mane decreases blood glucose level and increases serum insulin levels.<span class=\"custom-citation\" data-id=\"ref-30\"><\/span><\/p>\n\n\n\n<p>However, clinical studies regarding this benefit of lion\u2019s mane are lacking, so it\u2019s unclear whether lion\u2019s mane can reliably improve blood sugar in humans.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lion\u2019s mane side effects&nbsp;<\/h2>\n\n\n\n<p>Lion\u2019s mane is generally recognized as safe. However, be aware of contraindications and the following side effects.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Allergies<\/h3>\n\n\n\n<p>If you have mushroom or fungi allergies, you should definitely avoid consuming lion\u2019s mane.&nbsp;<\/p>\n\n\n\n<p>A 63-year-old man sought hospital care 4 months after consuming lion\u2019s mane, where he got severe acute respiratory failure diagnosis. He also had very high levels of lymphocytes, which might indicate an allergic reactions.<span class=\"custom-citation\" data-id=\"ref-31\"><\/span><\/p>\n\n\n\n<p>Beware of your allergies before consuming lion\u2019s mane.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Slow blood clotting<\/h3>\n\n\n\n<p>Some people benefit from the blood thinning effects of lion\u2019s mane. However, this means it can interact with blood thinner medications. If you naturally have slow coagulation or hemophilia, you should avoid lion\u2019s mane. Also, stop taking lion\u2019s mane at least two weeks before a scheduled surgery.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Too much lion\u2019s mane<\/h3>\n\n\n\n<p>Consuming too much lion\u2019s mane can cause stomach issues.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p>Lion\u2019s mane is a powerful medicinal mushroom with many brain and body benefits. Check out <a href=\"https:\/\/bioptimizers.com\/shop\/products\/collagenius\" target=\"_blank\" rel=\"noreferrer noopener\">Collagenius<\/a>, our potent Lion\u2019s mane and collagen blend.&nbsp;<\/p>\n\n\n\n<p>References<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><div id=\"ref-1\" class=\"custom-reference\">Spelman K, Sutherland E, Bagade A. <a href=\"https:\/\/restorativemedicine.org\/journal\/neurological-activity-lions-mane-hericium-erinaceus\/?utm_source=ojs&amp;utm_medium=web&amp;utm_campaign=journal\" target=\"_blank\" rel=\"noreferrer noopener\">Neurological Activity of Lion\u2019s Mane (Hericium erinaceus)<\/a>. <em>J Restor Med<\/em>. 2017;6(1):19-26. doi:10.14200\/jrm.2017.6.0108<\/div><\/li><li><div id=\"ref-2\" class=\"custom-reference\">Lai PL, Naidu M, Sabaratnam V, et al. <a href=\"https:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,034eeb045436a171,750a15ad12ae25e9.html\" target=\"_blank\" rel=\"noreferrer noopener\">Neurotrophic properties of the Lion\u2019s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia<\/a>. <em>Int J Med Mushrooms.<\/em> 2013;15(6):539-554. doi:10.1615\/intjmedmushr.v15.i6.30<\/div><\/li><li><div id=\"ref-3\" class=\"custom-reference\">Ryu SH, Hong SM, Khan Z, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33246107\/\" target=\"_blank\" rel=\"noreferrer noopener\">Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus.<\/a> <em>Bioorg Med Chem Lett<\/em>. 2021;31(127714):127714. doi:10.1016\/j.bmcl.2020.127714<\/div><\/li><li><div id=\"ref-4\" class=\"custom-reference\">Ghosh S, Nandi S, Banerjee A, Sarkar S, Chakraborty N, Acharya K. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/jfbc.13833\" target=\"_blank\" rel=\"noreferrer noopener\">Prospecting medicinal properties of Lion\u2019s mane mushroom<\/a>. <em>J Food Biochem<\/em>. 2021;45(8):e13833. doi:10.1111\/jfbc.13833<\/div><\/li><li><div id=\"ref-5\" class=\"custom-reference\">Friedman M. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5b02914\" target=\"_blank\" rel=\"noreferrer noopener\">Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (lion\u2019s mane) mushroom fruiting bodies and mycelia and their bioactive compounds<\/a>. <em>J Agric Food Chem<\/em>. 2015;63(32):7108-7123. doi:10.1021\/acs.jafc.5b02914<\/div><\/li><li><div id=\"ref-6\" class=\"custom-reference\">Miquel S, Champ C, Day J, et al. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163717302064\" target=\"_blank\" rel=\"noreferrer noopener\">Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions.<\/a> <em>Ageing Res Rev<\/em>. 2018;42:40-55. doi:10.1016\/j.arr.2017.12.004<\/div><\/li><li><div id=\"ref-7\" class=\"custom-reference\">Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18844328\/\" target=\"_blank\" rel=\"noreferrer noopener\">Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.<\/a> <em>Phytother Res<\/em>. 2009;23(3):367-372. doi:10.1002\/ptr.2634<\/div><\/li><li><div id=\"ref-8\" class=\"custom-reference\">Li IC, Lee LY, Tzeng TT, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5987239\/\" target=\"_blank\" rel=\"noreferrer noopener\">Neurohealth properties ofHericium erinaceusMycelia enriched with erinacines<\/a>. <em>Behav Neurol.<\/em> 2018;2018:1-10. doi:10.1155\/2018\/5802634<\/div><\/li><li><div id=\"ref-9\" class=\"custom-reference\">Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4895996\/\" target=\"_blank\" rel=\"noreferrer noopener\">High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity<\/a>.<em> BMC Complement Altern Med.<\/em> 2016;16(1):170. doi:10.1186\/s12906-016-1154-5<\/div><\/li><li><div 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href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29091526\/\" target=\"_blank\" rel=\"noreferrer noopener\"> Hericium erinaceus extract reduces anxiety and depressive behaviors by promoting hippocampal neurogenesis in the adult mouse brain.<\/a> <em>J Med Food<\/em>. 2018;21(2):174-180. doi:10.1089\/jmf.2017.4006<\/div><\/li><li><div id=\"ref-13\" class=\"custom-reference\">Chiu CH, Chyau CC, Chen CC, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29364170\/\" target=\"_blank\" rel=\"noreferrer noopener\">Erinacine A-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF\/PI3K\/Akt\/GSK-3\u03b2 signaling in mice.<\/a> <em>Int J Mol Sci<\/em>. 2018;19(2). doi:10.3390\/ijms19020341<\/div><\/li><li><div id=\"ref-14\" class=\"custom-reference\">Nagano M, Shimizu K, Kondo R, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20834180\/\" target=\"_blank\" rel=\"noreferrer noopener\">Reduction of depression and anxiety by 4 weeks Hericium erinaceus 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vitro study<\/a>. <em>Int J Med Mushrooms<\/em>. 2015;17(11):1047-1054. doi:10.1615\/intjmedmushrooms.v17.i11.40<\/div><\/li><li><div id=\"ref-17\" class=\"custom-reference\">Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12675022\/\" target=\"_blank\" rel=\"noreferrer noopener\">The influence of Hericium erinaceus extract on myelination process in vitro.<\/a> <em>Fiziol Zh<\/em>. 2003;49(1):38-45. Accessed September 16, 2022. https:\/\/pubmed.ncbi.nlm.nih.gov\/12675022\/<\/div><\/li><li><div id=\"ref-18\" class=\"custom-reference\">Park YS. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3449638\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells.<\/a> <em>Cytotechnology<\/em>. 2002;39(3):155-162. doi:10.1023\/a:1023963509393<\/div><\/li><li><div id=\"ref-19\" class=\"custom-reference\">Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP. <a href=\"https:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,72e9ed69099c0eef,38819de325d881b2.html\" target=\"_blank\" rel=\"noreferrer noopener\">In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion\u2019s Mane mushroom, Hericium erinaceus (higher Basidiomycetes).<\/a> <em>Int J Med Mushrooms<\/em>. 2013;15(2):165-174. doi:10.1615\/intjmedmushr.v15.i2.50<\/div><\/li><li><div id=\"ref-20\" class=\"custom-reference\">Wang M, Konishi T, Gao Y, Xu D, Gao Q. <a href=\"https:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,343363596ed9bda8,006faf937d2f02af.html\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of lion\u2019s mane medicinal mushroom, Hericium erinaceus (higher basidiomycetes).<\/a> <em>Int J Med Mushrooms<\/em>. 2015;17(11):1055-1060. doi:10.1615\/intjmedmushrooms.v17.i11.50<\/div><\/li><li><div id=\"ref-21\" class=\"custom-reference\">Mori K, Kikuchi H, Obara Y, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20637576\/\" target=\"_blank\" rel=\"noreferrer noopener\">Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation<\/a>. <em>Phytomedicine<\/em>. 2010;17(14):1082-1085. doi:10.1016\/j.phymed.2010.05.004<\/div><\/li><li><div id=\"ref-22\" class=\"custom-reference\">Hiwatashi K, Kosaka Y, Suzuki N, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20622452\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet<\/a>. <em>Biosci Biotechnol Biochem.<\/em> 2010;74(7):1447-1451. doi:10.1271\/bbb.100130<\/div><\/li><li><div id=\"ref-23\" class=\"custom-reference\">Qin M, Geng Y, Lu Z, et al. <a href=\"https:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,23ce65314f371f4f,5d11b27c03b8f781.html\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-inflammatory effects of ethanol extract of lion\u2019s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), in mice with ulcerative colitis.<\/a> <em>Int J Med Mushrooms<\/em>. 2016;18(3):227-234. doi:10.1615\/IntJMedMushrooms.v18.i3.50<\/div><\/li><li><div id=\"ref-24\" class=\"custom-reference\">Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21716693\/\" target=\"_blank\" rel=\"noreferrer noopener\"> Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities.<\/a> <em>Evid Based Complement Alternat Med<\/em>. 2012;2012:464238. doi:10.1155\/2012\/464238<\/div><\/li><li><div id=\"ref-25\" class=\"custom-reference\">Kushairi N, Phan CW, Sabaratnam V, David P, Naidu M. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31374912\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lion\u2019s mane mushroom, Hericium erinaceus (bull.: Fr.) pers. Suppresses H2O2-induced oxidative damage and LPS-induced inflammation in HT22 hippocampal neurons and BV2 microglia.<\/a> <em>Antioxidants (Basel).<\/em> 2019;8(8):261. doi:10.3390\/antiox8080261<\/div><\/li><li><div id=\"ref-26\" class=\"custom-reference\">Sheng X, Yan J, Meng Y, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28266682\/\" target=\"_blank\" rel=\"noreferrer noopener\">Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology<\/a>. <em>Food Funct<\/em>. 2017;8(3):1020-1027. doi:10.1039\/c7fo00071e<\/div><\/li><li><div id=\"ref-27\" class=\"custom-reference\">Kim SP, Moon E, Nam SH, Friedman M. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22624604\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells<\/a>. <em>J Agric Food Chem<\/em>. 2012;60(22):5590-5596. doi:10.1021\/jf300897w<\/div><\/li><li><div id=\"ref-28\" class=\"custom-reference\">Mori K, Ouchi K, Hirasawa N. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26559695\/\" target=\"_blank\" rel=\"noreferrer noopener\">The anti-inflammatory effects of lion\u2019s mane culinary-medicinal mushroom, Hericium erinaceus (higher basidiomycetes) in a coculture system of 3T3-L1 adipocytes and RAW264 macrophages<\/a>. <em>Int J Med Mushrooms<\/em>. 2015;17(7):609-618. doi:10.1615\/intjmedmushrooms.v17.i7.10<\/div><\/li><li><div id=\"ref-29\" class=\"custom-reference\">Wu T, Xu B. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25746618\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antidiabetic and antioxidant activities of eight medicinal mushroom species from China<\/a>. <em>Int J Med Mushrooms<\/em>. 2015;17(2):129-140. doi:10.1615\/intjmedmushrooms.v17.i2.40<\/div><\/li><li><div id=\"ref-30\" class=\"custom-reference\">Liang B, Guo Z, Xie F, Zhao A. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3852124\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. <\/a><em>BMC Complement Altern Med<\/em>. 2013;13(1):253. doi:10.1186\/1472-6882-13-253<\/div><\/li><li><div id=\"ref-31\" class=\"custom-reference\">Nakatsugawa M, Takahashi H, Takezawa C, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14714963\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hericium erinaceum (yamabushitake) extract-induced acute respiratory distress syndrome monitored by serum surfactant proteins<\/a>. <em>Intern Med<\/em>. 2003;42(12):1219-1222. doi:10.2169\/internalmedicine.42.1219<\/div><\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Lion\u2019s mane, or Hericium erinaceus, is an edible mushroom which is a part of traditional Asian medicine. It\u2019s the most popular mushroom for its nootropics and neurogenesis benefits. In this article, we will cover everything you need to know about lion\u2019s mane, from benefits to side effects.&nbsp; What is Lion&#8217;s Mane mushroom?\u00a0 Lion\u2019s mane (Yamabushitake [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":1040,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>All About Lion&#039;s Mane - Benefits, Side Effects, and More<\/title>\n<meta name=\"description\" content=\"Lion\u2019s mane is an edible mushroom with medicinal properties and a long list of benefits. 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