{"id":1242,"date":"2023-04-11T20:49:49","date_gmt":"2023-04-11T20:49:49","guid":{"rendered":"https:\/\/nootopia.com\/blog\/?p=1242"},"modified":"2023-04-11T20:49:50","modified_gmt":"2023-04-11T20:49:50","slug":"california-poppy-seed-extract","status":"publish","type":"post","link":"https:\/\/nootopia.com\/blog\/california-poppy-seed-extract\/","title":{"rendered":"California Poppy Seed Extract"},"content":{"rendered":"\n<p>Recognized by its beautiful orange flowers, California Poppy (<em>Eschscholzia californica<\/em>) grows across North America. Native Americans utilized this plant in their daily meals and their medicine. In this article, we will cover how California Poppy improves sleep, helps you relax, and more.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Alkaloids And Their Biosynthesis<\/h2>\n\n\n\n<p>Benzylisoquinoline alkaloids are metabolites with a wide range of effects, including relaxation and discomfort relief. California Poppy plants produce these alkaloids.<\/p>\n\n\n\n<p>Sanguinarine is a major benzylisoquinoline alkaloid originating from California Poppy. This alkaloid inhibits bacterial growth, and is even an ingredient found in toothpaste <span class=\"custom-citation\" data-id=\"ref-1\"><\/span>. Other alkaloids extracted from Eschscholzia californica are californidine, escholtzine, and caryachine <span class=\"custom-citation\" data-id=\"ref-2\"><\/span>.<\/p>\n\n\n\n<p>WRKY transcription factors play a role in alkaloid biosynthesis across plant species. California Poppy possesses 50 WRKY genes, with different expression levels across plant parts <span class=\"custom-citation\" data-id=\"ref-3\"><\/span>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Benefits Of California Poppy Seed Extract<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Sleep<\/h3>\n\n\n\n<p>California Poppy seed extract can improve your sleep. In a study, mice received between 100 and 200 mg\/kg body weight of California Poppy extract. Doses above 100 mg\/kg induced sleep in mice <span class=\"custom-citation\" data-id=\"ref-4\"><\/span>.<\/p>\n\n\n\n<p>The alkaloids act on GABA receptors. GABA is an inhibitory neurotransmitter which can promote sleep <span class=\"custom-citation\" data-id=\"ref-5\"><\/span>.<\/p>\n\n\n\n<p>A study included 22 individuals who struggled with sleep. They received a maximum of 4 pills every night for a month. The pills contained 80 mg of California Poppy extract and 32 mg of Valeriana officinalis extract.<\/p>\n\n\n\n<p>The results after one month were:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Sleep struggles decreased by 30%<\/strong><\/li>\n\n\n\n<li>Total duration of sleep increased by 30 minutes<\/li>\n\n\n\n<li><strong>The efficiency of sleep increased from 78% to almost 85%<\/strong><\/li>\n\n\n\n<li>Waking up during the night decreased by 25% <span class=\"custom-citation\" data-id=\"ref-6\"><\/span>.<\/li>\n<\/ul>\n\n\n\n<p>30 patients with similar sleep issues received 20 drops of either <em>Eschscholzia californica<\/em> or <em>Passiflora incarnata<\/em> (passionflower) extract at bedtime for 40 days. Individuals in the California Poppy group slept 59 minutes longer than the passionflower group <span class=\"custom-citation\" data-id=\"ref-7\"><\/span>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Calming Effects<\/h3>\n\n\n\n<p>California Poppy seed extract promotes relaxation. In a mice study, California Poppy extract dosage of 25 mg\/kg body weight induced calm behavior <span class=\"custom-citation\" data-id=\"ref-8\"><\/span>.<\/p>\n\n\n\n<p>Moreover, another study demonstrated similar results. Mice received 25 mg\/kg body weight of California Poppy extract. The staircase test showed anti conflict effects in the California Poppy group. Additionally, the poppy seed group spent more time in the lit box during the light\/dark choice test <span class=\"custom-citation\" data-id=\"ref-4\"><\/span>.<\/p>\n\n\n\n<p>Another study included 264 individuals. One group received a placebo, and the other group received tablets containing Crataegus oxyacantha and Eschscholtzia californica extracts for 3 months. Individuals experienced significant improvement in their mood. They also reported increased feelings of calmness <span class=\"custom-citation\" data-id=\"ref-9\"><\/span>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Reduces Discomfort<\/h3>\n\n\n\n<p>California Poppy seeds impact discomfort relief. A mice study showed that supplementation with this plant extract reduced discomfort in mice. Animals performed less discomfort-reducing activities, such as twitching, jerking, and stretching <span class=\"custom-citation\" data-id=\"ref-8\"><\/span>.<\/p>\n\n\n\n<p>A rat study dealt with effects of California Poppy extract on discomfort perception and peripheral nervous system issues. The injection dose was between 100 and 300 mg\/kg body weight.<br>A single dose significantly reduced discomfort perception in rats. Thermal and other stimuli had no effects on rats, as California Poppy extract inhibited the aching sensations <span class=\"custom-citation\" data-id=\"ref-10\"><\/span>.<\/p>\n\n\n\n<p>Try <a href=\"https:\/\/nootopia.com\/dream-optimizer\/\">Dream Optimizer<\/a>, which contains California Poppy extract. Spray <a href=\"https:\/\/nootopia.com\/dream-optimizer\/\">Dream Optimizer<\/a> under your tongue and then swallow after 30 seconds. Feel the calming effects within minutes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Side Effects Of California Poppy Seed Extract&nbsp;<\/h2>\n\n\n\n<p>As California Poppy seed extract promotes relaxation and calmness, supplementation can cause slowed breathing and sleepiness.<\/p>\n\n\n\n<p>In the human study, the pill containing 80 mg of California Poppy extract (and one more ingredient) caused frequent urination in one participant <span class=\"custom-citation\" data-id=\"ref-6\"><\/span>.<\/p>\n\n\n\n<p>11.5% of participants who received Eschscholzia californica extract (plus another plant extract) had mild digestive issues in another human study <span class=\"custom-citation\" data-id=\"ref-9\"><\/span>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion:<\/h2>\n\n\n\n<p>California Poppy seed extract is a safe and effective sleep and relaxation remedy. However, it\u2019s not for everyone, as some people experience some side effects. When in doubt, consult a qualified naturopathic doctor before introducing a new supplement.<\/p>\n\n\n\n<p>References:<\/p>\n\n\n<div id=\"ref-1\" class=\"custom-reference\">1. Yamada Y, Hirakawa H, Hori K, et al. Comparative analysis using the draft genome sequence of California poppy (Eschscholzia californica) for exploring the candidate genes involved in benzylisoquinoline alkaloid biosynthesis. Biosci Biotechnol Biochem. 2021;85(4):851-859.<\/div>\n\n\n<div id=\"ref-2\" class=\"custom-reference\">2. Stefan Gafner, Birgit M. Dietz, Kerry L. McPhail, Ian M. Scott, Jan A. Glinski, Fiona E. Russell, Megan M. McCollom, Jason W. Budzinski, Brian C. Foster, Chantal Bergeron, Mee-Ra Rhyu, and Judy L. Bolton. Alkaloids from Eschscholzia californica and Their Capacity to Inhibit Binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A Receptors in Vitro#. ACS Publications. Published online February 22, 2006. https:\/\/pubs.acs.org\/doi\/full\/10.1021\/np058114h<\/div>\n\n\n<div id=\"ref-3\" class=\"custom-reference\">3. Yamada Y, Nishida S, Shitan N, Sato F. Genome-Wide Profiling of WRKY Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in California Poppy (Eschscholzia californica). Front Plant Sci. 2021;12:699326.<\/div>\n\n\n<div id=\"ref-4\" class=\"custom-reference\">4. Rolland A, Fleurentin J, Lanhers MC, et al. Behavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic properties. Planta Med. 1991;57(3):212-216.<\/div>\n\n\n<div id=\"ref-5\" class=\"custom-reference\">5. Fedurco M, Gregorov\u00e1 J, \u0160ebrlov\u00e1 K, et al. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors. Biochem Res Int. 2015;2015:617620.<\/div>\n\n\n<div id=\"ref-6\" class=\"custom-reference\">6. Abdellah SA, Berlin A, Blondeau C, et al. A combination of Eschscholtzia californica Cham. and Valeriana officinalis L. extracts for adjustment insomnia: A prospective observational study. Afr J Tradit Complement Altern Med. 2020;10(2):116-123.<\/div>\n\n\n<div id=\"ref-7\" class=\"custom-reference\">7. Californica MT, In PIMT. A study to compare the efficacy of Eschscholzia. Accessed April 5, 2023. https:\/\/www.homoeopathicjournal.com\/articles\/89\/3-2-27-387.pdf<\/div>\n\n\n<div id=\"ref-8\" class=\"custom-reference\">8. Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier F. Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytother Res. 2001;15(5):377-381.<\/div>\n\n\n<div id=\"ref-9\" class=\"custom-reference\">9. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin. 2004;20(1):63-71.<\/div>\n\n\n<div id=\"ref-10\" class=\"custom-reference\">10. Vivoli E, Maidecchi A, Bilia AR, Galeotti N, Norcini M, Ghelardini C. Antihyperalgesic Effect of Eschscholzia Californica in Rat Models of Neuropathic Pain. Nat Prod Commun. 2008;3(12):1934578X0800301230.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Recognized by its beautiful orange flowers, California Poppy (Eschscholzia californica) grows across North America. Native Americans utilized this plant in their daily meals and their medicine. In this article, we will cover how California Poppy improves sleep, helps you relax, and more. Alkaloids And Their Biosynthesis Benzylisoquinoline alkaloids are metabolites with a wide range of [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":950,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>California Poppy Seed Extract - Nootopia Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nootopia.com\/blog\/california-poppy-seed-extract\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"California Poppy Seed Extract - Nootopia Blog\" \/>\n<meta property=\"og:description\" content=\"Recognized by its beautiful orange flowers, California Poppy (Eschscholzia californica) grows across North America. 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