Neuroplasticity Supplements, Herbs, and Nootropics

Some supplements may support cognitive function and brain health, which could indirectly contribute to neuroplasticity. However, the effects can vary based on factors such as the specific supplement, individual differences, dosage, and overall health.

Certain nutrients and compounds found in supplements for neuroplasticity may play a role in supporting brain health and cognitive function, which can contribute to an environment that supports neuroplasticity.

What Are Neuroplasticity Supplements, Herbs, Nootropics, and How Do They Work?

Omega-3 Fatty Acids 

Omega-3s, found in fish and algae oil supplements, are important for brain health.

They can potentially increase neuroplasticity through several mechanisms:

Enhancing Neuronal Membrane Fluidity 

Omega-3s, such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are essential components of neuronal cell membranes. They help maintain the fluidity and flexibility of these membranes, which is crucial for efficient communication between neurons. Flexible membranes allow for easier transmission of signals and the formation of new connections, supporting neuroplasticity.

Promoting Synaptic Function 

The proper functioning of synapses is essential for learning and memory. Omega-3s may help optimize synaptic transmission and facilitate the strengthening of synaptic connections, which are vital aspects of neuroplasticity.

Supporting Healthy Inflammatory Response

Inflammation in the brain can hinder neuroplasticity by disrupting communication between neurons. Omega-3 fatty acids support healthy inflammatory responses in the nervous system. Therefore,omega-3s create a more conducive environment for neural connections to form and adapt, thereby supporting neuroplasticity.

Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels

BDNF is a protein that promotes the growth, survival, and maintenance of neurons. It is also involved in the formation of new synapses and the adaptation of existing ones, both of which are fundamental processes in neuroplasticity. 

Omega-3 fatty acids, particularly DHA, increase BDNF levels in the brain, facilitating neural connectivity and enhancing the brain’s adaptive capacity.

Modulating Neurotransmitters 

Omega-3s can influence the production and release of neurotransmitters like dopamine, serotonin, and glutamate. These neurotransmitters play central roles in cognitive processes and mood regulation. By helping regulate the balance of neurotransmitters, omega-3s can support overall brain function and emotional well-being, which are integral components of neuroplasticity.

Antioxidants 

Antioxidants can potentially increase neuroplasticity through their ability to neutralize oxidative stress, which can impair the brain’s adaptive capacity. Antioxidants support neuroplasticity in the following ways:

Reducing Oxidative Stress (ROS)

Oxidative stress occurs when there is an imbalance between harmful ROS and the body’s antioxidant defenses. Excessive oxidative stress can damage neurons and their components, including DNA, proteins, and lipids. 

Antioxidants neutralize ROS and help protect neurons from this damage, preserving their function and viability. Healthy neurons are better equipped to engage in neuroplasticity.

 Protecting Mitochondrial Function

Mitochondria are the energy-producing organelles within neurons. Oxidative stress can impair mitochondrial function, leading to energy deficits and decreased neuronal plasticity. Antioxidants can help maintain mitochondrial health by mitigating oxidative damage, ensuring neurons have the energy they need to support neuroplasticity.

Inflammation Modulating Effects 

Unmodulated Chronic inflammation in the brain can hinder neuroplasticity by disrupting the normal functioning of neurons and glial cells. Antioxidants, by modulating inflammation, create a more favorable environment for neural plasticity. They can modulate immune responses, supporting overall brain health.

 Promoting BDNF Production

As previously mentioned, BDNF is a protein that plays a crucial role in neuroplasticity. Some antioxidants, such as flavonoids found in certain fruits and vegetables, increase the production of BDNF. Elevated BDNF levels facilitate the formation of new synapses and strengthen existing ones, which are essential aspects of neuroplasticity.

B Vitamins 

B vitamins play an important role in brain health and can support neuroplasticity through several mechanisms:

 Neurotransmitter Production 

B vitamins, particularly B6 (pyridoxine), B9 (folate), and B12 (cobalamin), are essential for the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. Ensuring an adequate supply of these B vitamins helps maintain neurotransmitter balance, which is important for neuroplasticity.

 Homocysteine Regulation 

Elevated levels of homocysteine, an amino acid, are associated with an increased risk of cognitive decline. B vitamins, specifically folate, B6, and B12, help regulate homocysteine levels in the body. B vitamin supplementation may help reduce the risk of cognitive impairment and support overall brain health, including neuroplasticity.

 DNA Methylation and Synaptic Plasticity

DNA methylation is an epigenetic process that can influence gene expression. B vitamins, particularly folate, play a role in DNA methylation, which can affect the expression of genes involved in synaptic plasticity. Proper methylation patterns are necessary for the formation and strengthening of synaptic connections, a fundamental process in neuroplasticity.

 Protection Against Oxidative Stress 

B vitamins, including niacin (B3) and riboflavin (B2), are involved in your body’s antioxidant defenses. Antioxidants help protect neurons from oxidative stress, which can damage cell membranes, proteins, and DNA. By reducing oxidative stress, B vitamins support the health and function of neurons and facilitate neuroplasticity.

 Mood Regulation 

B vitamins are known to play a role in mood regulation, and mood is closely linked to cognitive function and neuroplasticity. For example, B6 is involved in the production of serotonin, a mood-enhancing neurotransmitter. Balancing mood can indirectly support cognitive processes and neuroplasticity.

A balanced diet with foods rich in B vitamins, such as leafy greens, legumes, nuts, and fortified cereals, can provide the necessary nutrients to support brain health and neuroplasticity. However, in cases of deficiency or certain medical conditions, B vitamin supplementation may be recommended under the guidance of a healthcare professional. 

Lion’s Mane Mushroom (Hericium erinaceus)

Lion’s mane mushroom (Hericium erinaceus) is a natural dietary supplement that has gained attention for its potential to support neuroplasticity and overall brain health. While the exact mechanisms of how lion’s mane mushroom influences neuroplasticity are still being researched, there are several ways it may contribute to this process:

 Nerve Growth Factor (NGF) and pro-BDNF Stimulation 

Lion’s Mane Mushroom contains compounds known as hericenones and erinacines, which have been shown in some studies to stimulate the production of nerve growth factor (NGF). NGF is a protein essential for the growth, maintenance, and survival of neurons. 

By promoting NGF production, Lion’s Mane Mushroom may facilitate the growth of new neurites (extensions of nerve cells) and the formation of new synaptic connections, which are key aspects of neuroplasticity.

Lion’s Mane Mushroom supplements increase levels of pro-BDNF, which is a precursor to BDNF. Pro-BDNF is synthesized and released by neurons and is involved in synaptic pruning which is an important process of neuroplasticity. 

 Enhanced Myelination 

Myelin is the protective sheath that covers nerve fibers and enhances the efficiency of signal transmission between neurons. Lion’s Mane Mushroom may support myelination by promoting the growth and differentiation of oligodendrocytes, the cells responsible for myelin production. 

Improved myelination can lead to faster and more efficient communication between neurons, potentially enhancing neuroplasticity.

 Antioxidant Properties 

Lion’s Mane Mushroom is rich in antioxidants, which help combat oxidative stress and reduce damage to neurons caused by free radicals. Oxidative stress can impair neuronal function and hinder neuroplasticity. By reducing oxidative stress, Lion’s Mane Mushroom may create a more favorable environment for synaptic plasticity and neural adaptation.

 Inflammation-Balancing Effects

Lion’s Mane Mushroom has immune-balancing properties, which may help promote a healthy inflammatory response and thus a healthier environment for synaptic remodeling and plasticity.

 Improved Cognitive Function 

Some studies suggest that lion’s mane mushroom supplementation can lead to improved cognitive function, including memory and learning. Enhanced cognitive abilities can indirectly support neuroplasticity by facilitating the acquisition of new information and the formation of new neural connections.

While there is promising research on the potential benefits of Lion’s Mane Mushroom for neuroplasticity, more studies are needed to fully understand its mechanisms and effects. 

Individual responses to Lion’s Mane Mushroom may vary, and its use should be approached with caution, especially if you have any underlying medical conditions or are taking medications. As with any dietary supplement, it’s advisable to consult with a healthcare professional before incorporating lion’s mane mushroom into your routine.

Caffeine

Caffeine is a stimulant that primarily affects the central nervous system, and while it is more commonly associated with increasing alertness and concentration, it can also have some indirect effects on neuroplasticity.

 Enhanced Cognitive Function

Although there is no clear consensus, some studies suggest that caffeine can temporarily improve cognitive function, including attention, memory, and learning. 

By increasing alertness and mitigating the sensation of fatigue, caffeine may help individuals engage more effectively in cognitive tasks that require neuroplasticity, such as learning new information or adapting to changing circumstances. This enhanced cognitive function can indirectly support neuroplasticity by facilitating the acquisition and processing of new information.

 Stimulation of Neurotransmitter Release 

Caffeine stimulates the release of certain neurotransmitters, including dopamine and norepinephrine, in the brain. These neurotransmitters play roles in mood regulation, attention, and arousal. Increased neurotransmitter activity can enhance alertness and focus, potentially aiding in the engagement of cognitive processes associated with neuroplasticity.

 Improved Synaptic Transmission 

Caffeine can enhance synaptic transmission, the process by which signals are transmitted between neurons at synapses. It can increase the release of neurotransmitters like glutamate, which is crucial for synaptic plasticity and learning. 

By promoting more efficient signaling between neurons, caffeine can indirectly support the strengthening and formation of neural connections, essential aspects of neuroplasticity.

 Neuroprotective Effects 

Some studies suggest that caffeine has neuroprotective properties, which means it may help protect neurons from damage caused by factors like oxidative stress and neuroinflammation. By preserving the health of neurons, caffeine can create a more conducive environment for neuroplasticity to occur.

By blocking adenosine receptors, caffeine enhances alertness, potentially influencing neural activity and learning. This heightened neuronal firing, along with potential BDNF elevation, might foster an environment conducive to neuroplasticity. However, individual responses to caffeine vary, and excessive intake can lead to negative effects.

The caffeine’s effect on neuroplasticity can vary among individuals and depend on factors such as the dose of caffeine consumed and an individual’s tolerance to caffeine. 

While moderate caffeine consumption may have some potential cognitive benefits, excessive caffeine intake can lead to side effects, including anxiety, jitteriness, and disrupted sleep, which can ultimately impair cognitive function and neuroplasticity.

Additionally, the long-term effects of chronic caffeine use on neuroplasticity are still an active area of research, and more studies are needed to fully understand the relationship between caffeine and brain plasticity. It’s advisable to consume caffeine in moderation and be mindful of its potential side effects, especially if you have underlying medical conditions or are sensitive to caffeine.

Bacopa Monnieri

Bacopa monnieri, commonly known as Brahmi, is an herb used in traditional medicine, particularly in Ayurveda, that is believed to have several cognitive-enhancing properties, including the potential to increase neuroplasticity. 

Although no research has directly shown that Bacopa monnieri directly causes neuroplasticity, here are some ways Bacopa monnieri may influence neuroplasticity:

 Enhanced Synaptic Transmission

Bacopa monnieri is thought to enhance synaptic transmission, which is the process by which neurons communicate at synapses. It may increase the release of neurotransmitters like acetylcholine, which is important for learning and memory. 

Improved synaptic transmission can facilitate the strengthening and formation of neural connections, a key aspect of neuroplasticity.

 Neuroprotective Effects

Bacopa monnieri is rich in antioxidants, which help protect neurons from oxidative stress and damage caused by free radicals. By preserving the health of neurons, Bacopa monnieri can create a more conducive environment for neuroplasticity to occur.

 Modulation of Neurotransmitters 

Bacopa monnieri may influence the levels and activity of various neurotransmitters, including serotonin, dopamine, and GABA (gamma-aminobutyric acid). Modulating neurotransmitter activity can indirectly support neuroplasticity by enhancing cognitive function and emotional well-being.

 Stress Reduction 

Chronic stress can impair cognitive function and hinder neuroplasticity. Bacopa monnieri may promote calmness and enhance mood. By mitigating stress, it can create a more favorable environment for the brain to engage in neuroplasticity processes.

 Enhanced Memory Consolidation

Bacopa monnieri may help with improved memory retention and consolidation. The formation of long-term memories involves synaptic plasticity, and enhancing memory processes can indirectly support neuroplasticity.

 Neurotrophic Factor Modulation

Some research suggests that Bacopa monnieri may influence the expression of brain-derived neurotrophic factor (BDNF), a protein critical for the growth, survival, and adaptability of neurons. Elevated BDNF levels facilitate the formation of new synapses and the strengthening of existing ones, fundamental processes in neuroplasticity.

Supplements, herbs, and nootropics show promise in enhancing neuroplasticity, which is crucial for brain adaptability and cognitive health. Omega-3 fatty acids, antioxidants, B vitamins, Lion’s Mane Mushroom, and caffeine can potentially support neuroplasticity through various mechanisms. 

These compounds aid in maintaining neuronal health, promoting synaptic function, balancing inflammation, and enhancing neurotransmitter activity. 

While these supplements offer exciting potential, individual responses vary, necessitating consultation with healthcare professionals, especially for those with underlying health conditions. A well-balanced diet rich in these nutrients can also contribute to brain health and cognitive adaptability. 

These supplements offer a promising avenue for individuals seeking to improve cognitive function and overall well-being.

References:

1. DiNicolantonio JJ, O’Keefe JH. The importance of marine omega-3s for brain development and the prevention and treatment of behavior, mood, and other brain disorders. Nutrients. 2020;12(8):2333. doi:10.3390/nu1208233
2. Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008;9(7):568-578. doi:10.1038/nrn2421
3. Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology. Pharmacol Rev. 2018;70(1):12-38. doi:10.1124/pr.117.014092
4. Liao L, Pilotte J, Xu T, et al. BDNF induces widespread changes in synaptic protein content and up-regulates components of the translation machinery: An analysis using high-throughput proteomics. J Proteome Res. 2007;6(3):1059-1071. doi:10.1021/pr060358f
5. Healy-Stoffel M, Levant B. N-3 (omega-3) fatty acids: Effects on brain dopamine systems and potential role in the etiology and treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets. 2018;17(3):216-232. doi:10.2174/1871527317666180412153612
6. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative stress: Harms and benefits for human health. Oxid Med Cell Longev. 2017;2017:1-13. doi:10.1155/2017/8416763
7. Guo C, Sun L, Chen X, Zhang D. Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regeneration Research. 2013;8(21):2003. doi:10.3969/j.issn.1673-5374.2013.21.009
8. Mattson MP, Gleichmann M, Cheng A. Mitochondria in neuroplasticity and neurological disorders. Neuron. 2008;60(5):748-766. doi:10.1016/j.neuron.2008.10.010
9. DiSabato DJ, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. J Neurochem. 2016;139(S2):136-153. doi:10.1111/jnc.13607
10. Pisoschi AM, Pop A, Iordache F, et al. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy. Eur J Med Chem. 2022;232(114175):114175. doi:10.1016/j.ejmech.2022.114175
11. Cichon N, Saluk-Bijak J, Gorniak L, Przyslo L, Bijak M. Flavonoids as a natural enhancer of neuroplasticity—an overview of the mechanism of neurorestorative action. Antioxidants (Basel). 2020;9(11):1035. doi:10.3390/antiox9111035
12. Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2015;6(6):1164-1178. doi:10.5114/aoms.2015.56342
13. Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020;26(1):5-13. doi:10.1111/cns.13207
14. Garcia A. Homocysteine and cognitive function in elderly people. CMAJ. 2004;171(8):897-904. doi:10.1503/cmaj.1031586
15. Allison J, Kaliszewska A, Uceda S, Reiriz M, Arias N. Targeting DNA methylation in the adult brain through diet. Nutrients. 2021;13(11):3979. doi:10.3390/nu13113979
16. Kennedy D. B vitamins and the brain: Mechanisms, dose and efficacy—A review. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068
17. Lai PL, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the lion’s mane medicinal mushroom, Hericium erinaceus (higher basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-554. doi:10.1615/intjmedmushr.v15.i6.30
18. Vigna L, Morelli F, Agnelli GM, et al. Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity: Could circulating pro-BDNF and BDNF be potential biomarkers? Evid Based Complement Alternat Med. 2019;2019:1-12. doi:10.1155/2019/7861297
19. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fìzìol ž. 2003;49(1).
20. Ghosh S, Nandi S, Banerjee A, Sarkar S, Chakraborty N, Acharya K. Prospecting medicinal properties of Lion’s mane mushroom. J Food Biochem. 2021;45(8). doi:10.1111/jfbc.13833
21. Mori K, Ouchi K, Hirasawa N. The anti-inflammatory effects of lion’s mane culinary-medicinal mushroom, Hericium erinaceus (higher basidiomycetes) in a coculture system of 3T3-L1 adipocytes and RAW264 macrophages. Int J Med Mushrooms. 2015;17(7):609-618. doi:10.1615/intjmedmushrooms.v17.i7.10
22. Rossi P, Cesaroni V, Brandalise F, et al. Dietary supplementation of lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice. Int J Med Mushrooms. 2018;20(5):485-494. doi:10.1615/intjmedmushrooms.2018026241
23. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016;71:294-312. doi:10.1016/j.neubiorev.2016.09.001
24. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Rev. 1992;17(2):139-170. doi:10.1016/0165-0173(92)90012-b
25. Yoshimura H. The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain. Curr Neuropharmacol. 2005;3(4):309-316. doi:10.2174/157015905774322543
26. Wasim S, Kukkar V, Awad VM, Sakhamuru S, Malik BH. Neuroprotective and neurodegenerative aspects of coffee and its active ingredients in view of scientific literature. Cureus. 2020;12(8). doi:10.7759/cureus.9578
27. Walker EA, Pellegrini MV. Bacopa Monnieri. StatPearls Publishing; 2023.
28. Brown W. Bacopa Monnieri Research Analysis. Published online 2023. Accessed September 27, 2023.
29. Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderly subjects. Journal of Clinical and Translational Research. 2023;9(1):50.
30. Simpson T, Pase M, Stough C. Bacopa monnierias an antioxidant therapy to reduce oxidative stress in the aging brain. Evid Based Complement Alternat Med. 2015;2015:1-9. doi:10.1155/2015/615384
31. Rajan KE, Preethi J, Singh HK. Molecular and Functional Characterization ofBacopa monniera: A Retrospective Review. Evid Based Complement Alternat Med. 2015;2015:1-12. doi:10.1155/2015/945217
32. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707-713. doi:10.1089/acm.2008.0018