Part 2: Personalized Nootropic Stacks for Brain Fog

In this article, part 2, we’ll explain how Nootopia's personalized nootropics can uniquely help with your brain fog.
Reviewed by Wendy Ugalde

As discussed in Part 1, brain fog can arise from nutritional and lifestyle factors. Often, failing to address the root causes and introducing nootropics or stimulants can worsen brain fog. 

Most nootropic products on the market may address one or two causes of brain fog. Whereas, Nootopia combines layers of ingredients to eliminate brain fog. Also, we have had decades and 10,000s of data points to personalize formulas based on our customer’s health history, tendency, and symptoms. 


Adaptogens are a class of plant and mushroom medicine that strengthen and tone your body and brain amidst stress. They don’t have any one action that confers their health benefits. Rather, they do many things throughout the body with synergistic benefits.

The three criteria of adaptogens include:

  1. Increase your resistance against adverse conditions by a variety of ways that work synergistically for overall benefits.
  2. Maintain your homeostasis by balancing the physical effects of external stresses.
  3. Must not harm the normal functions of the body.
3D render of a brain

Adaptogens are often stimulants, but they work differently than coffee. The benefits of adaptogens for brain fog include:

  • Promote stress resilience
  • Modulate inflammation
  • Provide antioxidant support
  • Promotes healthy blood sugar balance
  • Stimulating to cognitive function
  • Support balanced energy levels

For example, Nootopia’s Power Solution contains Rhodiola, one of the most well-known and researched plant adaptogens. 

Rhodiola has been used for thousands of years. It is a relatively stimulating adaptogen. In human studies, Rhodiola improves:

  • Cognitive function
  • Attention
  • Overall mood
  • Work
  • Social and family life
  • Energy
  • And quality of life.

Rhodiola improves energy levels by increasing energy production in cells. It also regulates and normalizes the release of stress hormones. 

Constituents That Address Inflammation

Inflammation can be a nemesis for your cognitive functions. Without addressing inflammation, you’re fighting an uphill battle. This is why we include inflammation-balancing ingredients in every dose.

Inflammation has many causes and different ways of manifesting. Hitting inflammation from different angles ensures a more effective and balanced response. Equally important to improve brain fog and optimize nootropics is addressing both systemic and neuroinflammation.

One ingredient you’ll find in Nootopia formulas that addresses inflammation in a holistic way is curcumin. Curcumin regulates a variety of steps in inflammation pathways. It also works both inside and outside the brain. 

curcumin inflammation pathways

In this image, the red curcumin annotations are places in cell inflammation processes that curcumin inhibits. 

Some of these are cell signals, while others regulate inflammatory genes.

Vitamin D3 is another synergistic ingredient present in multiple Nootopia products. Vitamin D helps maintain the balance in your immune system, so correcting a vitamin D deficiency tends to help with neuroinflammation.

Mitigates Lifestyle-Related Oxidative Stress

With oxidative stress being a primary driver of brain fog, a nootropic formula that doesn’t adequately fix this isn’t complete. Nootopia uses a number of powerful antioxidants to protect your neurons. The right antioxidants also allow them to fire in all cylinders without building up excess oxidative stress. 

These antioxidants protect the integrity of brain cell membranes from oxidative damage. Through providing unique nootropics along with antioxidant compounds, your brain can function at its prime and use the nootropics more effectively.

Some of our ingredients have multiple roles. Some of our ingredients that have antioxidant properties include:

  • Theobromine
  • Curcumin
  • Forskolin
  • Ascorbic acid
  • Piperine
  • Grape seed extract
  • Cilantro leaf

Provides Vitamin B Levels That Help Convert And Detox Neurotransmitters

B vitamins are a foundational part of energy metabolism. The brain is the most metabolically active organ in the human body and relies on high levels of B vitamins for healthy function. 

B vitamins can cross the blood brain barrier and the brain maintains high levels for energy production as well as neurotransmitter metabolism. For example, folate is 4 times higher in the brain than in blood. Brain levels of biotin and B5 can be 50 times higher than in the blood. 

The production of neurotransmitters, like acetylcholine, dopamine, and serotonin, relies on a number of B vitamins, such as B1, B5, and B6. Importantly, B vitamins also help detox neurotransmitters, supporting overall balance. 

If you need your brain to fire on all cylinders, it’s crucial to give it more building blocks and B vitamins that can cross the blood-brain barrier.

Boosts Acetylcholine Levels And Support Other Neurotransmitters 

Acetylcholine support is vital for getting rid of brain fog because of its neuromodulating properties. Our formulas contain unique amino acid blends and choline donors that support acetylcholine along with other neurotransmitters. This promotes balanced mood, memory, and learning. 

Pushing acetylcholine levels alone can also give you brain fog, however. Nootopia products are formulated to bring balance and synergy to acetylcholine. We also intentionally support all the other aspects of brain metabolism, like neurotransmitter breakdown and cellular energy production for this reason.

Our formulas also promote neurotransmitter balance in the brain, through supporting production of dopamine, serotonin, and GABA. This helps attain a calm and focused flow state.

Provides A Source Of DHA

DHA (Docosahexaenoic Acid) is the primary omega-3 fatty acid in the brain and is required for healthy neuronal function. DHA promotes brain health and decreases brain fog in these ways.

  • Modulates neuron signaling and neurotransmission
  • Promotes neurogenesis and myelination
  • Necessary for normal receptor function in cell membranes
  • Supports synaptic plasticity
  • Modulates neuroinflammation
  • Helps maintain cell membrane integrity

Our specific Celastrus paniculatus oil extract is a great source of plant-based DHA, which helps ensure our nootropics work to their highest potential.

Improve Brain Blood Flow And Oxygenation

blood brain barrier

Increasing cerebral blood flow ensures your brain gets all the oxygen, glucose, and other nutrients it needs to keep attention and cognitive function sharp. By increasing blood flow to your brain, nootropics also get there more easily and function at their peak.

Nootopia takes cerebral blood flow seriously. Ingredients like DHA, phosphatidylserine, rhodiola, and some of the Omnipepts improve brain blood flow. Importantly, by layering stimulants instead of relying on caffeine, you won’t experience the blood flow restriction effects of long-term caffeine reliance.

Support The Brain’s Housekeeping Functions

Sometimes the brain gets “gunked up” and we just need to clean house. You can imagine after a night of drinking alcohol, eating too much, or poor sleep, your brain can build up inflammation and oxidative stress.

Metabolic waste materials are also just part of having such a highly active organ as the brain..

Periodic housekeeping naturally happens while you sleep every night. Nootopia uses our specialized Mental Reboot stack to support this process. 

Our Mental Reboot AM and PM formulas contain ingredients that are scientifically proven to help “clean” your brain of excess oxidative by-products and waste materials that can impede neuron function.

How Does Nootopia Get You Into Your Personal Peak Flow State?

Many nootropic supplement companies focus on optimizing one or two areas of brain function that are supportive for the general user. Nootopia takes a more personalized approach. We recognize that everyone has unique genetics and biology that require optimization for peak cognitive function.

What is great for someone else might cause you to feel overstimulated, or vice versa. You may be very sensitive to particular ingredients and need different doses and frequencies, or even different formulas than someone else. 

Nootopia has developed a proprietary system to help you hone in on your exact, unique nootropic needs. We use nootropic brain stacks and an individualized assessment method to find the nootropics you need, how much, and when. 

As you’ve seen in this article, Nootopia takes a holistic approach to brain health not found in any other nootropic company. By customizing formulas specifically for your needs and simultaneously balancing the entire ecosystem of brain health, we get you into your peak flow state unlike anything you’ve experienced before.

How Our Method Works

The first step is to complete our neurotransmitter dominance quiz. This helps to know what general category you fit into.

After this, we have you fill out a detailed intake form. This gets us even closer to hitting your sweet spot. Using this information, we then customize your first batch of nootropics.

Over the first thirty days, you keep note of your cognitive function and symptoms in response to each formula and stack in the Nootopia app. Based on this info, we re-customize your nootropics. You do this each month, honing in each time closer and closer to your apex performance zone, until eventually, BHAM, you reach “God Mode”. 


Eliminating brain fog and getting to optimal cognitive performance takes a lot more than just putting a few nootropics together and hoping your biology uses them well. There are vital systems and obstacles to address, such as inflammation, oxidative stress, and brain cell metabolism.

Nootopia is the only nootropic company that focuses on your entire neurologic landscape, using holistic formulas and brain stacks.

There is also no other method like our 30-day guided journey that uncovers your individual neurologic needs. Using this approach, your nootropics are formulated for your specific biology and truly gets you into the clearest brain states you have ever experienced.

Take our neurotransmitter dominance quiz to find your zone! 


  1. Anghelescu IG, Edwards D, Seifritz E, Kasper S. Stress management and the role of Rhodiola rosea: a review. Int J Psychiatry Clin Pract. 2018;22(4):242-252. doi:10.1080/13651501.2017.1417442
  2. Peng Y, Ao M, Dong B, et al. Anti-inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures. Drug Des Devel Ther. 2021;15:4503-4525. doi:10.2147/DDDT.S327378
  3. Calvello R, Cianciulli A, Nicolardi G, et al. Vitamin D treatment attenuates neuroinflammation and dopaminergic neurodegeneration in an animal model of Parkinson’s disease, shifting M1 to M2 microglia responses. J Neuroimmune Pharmacol. 2017;12(2):327-339. doi:10.1007/s11481-016-9720-7
  4. Kennedy DO. B vitamins and the brain: Mechanisms, dose and efficacy–A review. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068
  5. Weiser MJ, Butt CM, Mohajeri MH. Docosahexaenoic Acid and Cognition throughout the Lifespan. Nutrients. 2016;8(2):99. doi:10.3390/nu8020099
Share this article using the buttons below
You'll enjoy these posts

Based on your reading history, we think you'll enjoy these posts...